About Stoke Therapeutics
What is Stoke Therapeutics?
Stoke Therapeutics describes itself in its adverts as a biotechnology company (Nasdaq: STOK) "dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine". Its proprietary platform is TANGO, short for Targeted Augmentation of Nuclear Gene Output, and the company develops antisense oligonucleotides (ASOs) to restore protein levels in diseases caused by a loss of about half of normal protein. The first medicine in development, zorevunersen (STK-001), is aimed at Dravet syndrome, a severe genetic epilepsy, and the homepage says a Phase 3 study is now underway. A second program targets autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The About page says Stoke was co-founded in 2014 by Professor Adrian Krainer and Isabel Aznarez, and the founders page says it "became a publicly-traded company in 2019". No page read states a headcount or a funding total, so neither is given here.
Where will I work?
The contact page lists the headquarters at 45 Wiggins Ave, Bedford, MA 01730, and 25 of the 26 adverts on the Greenhouse board are headed Bedford, Massachusetts (the other is headed only Hybrid). The company is changing site: the adverts say Stoke "will be moving to a new location in Waltham, MA by the end of 2026", and the Technology Services advert puts the move in December 2026 or January 2027. No page read gives the new address. On 13 November 2026 the board lists 26 adverts. In 19 of them the advert text itself says the role is remote or hybrid: 12 say hybrid, 3 say remote (the two Regional Medical Director roles and the Senior Director, National Accounts, a field role), 1 is remote with about one day a week on site and 3 are open to remote or hybrid candidates. The other 7 are not counted here: three are on-site, lab-based or primarily on-site roles (Technology Services, "an on-site position with work-from-home flexibility"; Lab Assistant; Product Communications), two are office-based (Investor Relations, Senior Scientist) and two state no arrangement (the VP, Non Clinical Development and VP, Pharmaceutical & Process Development adverts). Office-day counts are stated in only two adverts: Legal Operations says "2-3 days in office" and the Senior Clinical Trial Manager role is remote with about one day a week on site. Most adverts state travel of 30% or less; the two Regional Medical Directors state 50-70% domestic travel and National Accounts about 50%.
What is the Stoke Therapeutics team like?
The careers page calls Stoke "a highly collaborative workplace" and the About page lists three values: Show Up R.e.a.l., Speak Up & Deliver and Fire Up Fearless. The leadership page lists a Chief Executive Officer, a General Counsel, a Chief Financial Officer, a Chief Medical Officer, a Chief Scientific Officer, a Chief Regulatory Officer, a Chief People Officer and other officers, plus a board of nine. The open roles come from 13 departments (Manufacturing, IT, Medical Affairs, Regulatory Affairs and Finance have three each) and lean senior: 20 of the 26 titles are associate director or above, and 6 are vice president or senior vice president. Of the 19 remote or hybrid adverts, 15 are associate director or above. Eight adverts use the phrase "fast-paced", four ask for people who work "under pressure" and two mention urgency; the About page says "We are dedicated, persistent and work with a sense of urgency fueled by our passion to make a difference for patients." Every advert adds that Stoke believes innovation and "having fun as a team are enhanced by being together in person, at least periodically". All 26 adverts publish an anticipated salary range, from $65,000 for the Lab Assistant to $440,000 for the top of the Senior Vice President, Accounting and Vice President, Clinical Development ranges.
Work-Life Balance
The careers page says "Stoke offers flexible work schedules, professional development, tuition assistance, paid parental leave, and unlimited vacation time." All 26 adverts, across all 13 departments, repeat "unlimited vacation time" in their benefits sentence. No page or advert gives a minimum number of days, a holiday count, a shutdown or an approval rule, and none gives the length of the paid parental leave. The flexible work schedules line appears once, on the careers page, with no explanation: no advert mentions flexible hours, flexitime or core hours, and the adverts' own wording, "We allow for flexibility in work arrangements", concerns where people work. No advert mentions on-call or weekend work. Hybrid and remote roles are set role by role, and the adverts ask for periodic time together in person.
Perks and Benefits
- Unlimited vacation time (careers page and all 26 adverts)
- Medical, dental and vision insurance
- Life, long- and short-term disability insurance
- Paid parental leave (length not stated)
- 401K plan with company match
- Tuition assistance and professional development (careers page)
- Employee Stock Purchase Program (ESPP) and equity participation
- Annual bonus: adverts say Stoke offers an annual bonus and equity participation
- Flexible work schedules (careers page line, not defined)