About Spyre Therapeutics
What is Spyre Therapeutics?
Spyre Therapeutics is a clinical-stage biotechnology company that develops antibodies for immune-mediated diseases. Its homepage says the company is "committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients." The adverts describe the pipeline as "investigational extended half-life antibodies targeting α4β7, TL1A, IL-23, and IL-17A/F as well as rational combination programs." The pipeline page lists six ulcerative colitis programs in Phase 2 (SPY001, SPY002 and SPY003, plus the combinations SPY120, SPY130 and SPY230) with a Phase 2 proof-of-concept milestone shown for the third quarter of 2027, and two hidradenitis suppurativa programs, SPY072 and SPY772; for SPY072 it says "A pivotal trial of SPY072 in HS patients is planned for 2027". Every candidate is described as investigational and not approved for any use. The about page lists a leadership team with a Chief Executive Officer (Cameron Turtle), a Chief Financial Officer, a Chief Medical Officer and senior vice presidents for areas such as drug safety and pharmacovigilance, regulatory affairs and clinical development. The SEC's EDGAR record for Spyre Therapeutics, Inc. shows a Nasdaq listing under the ticker SYRE and a former name, Aeglea BioTherapeutics, Inc., used until 24 November 2023. No company page fetched states a founding year, a headcount or a funding total.
Where will I work?
All six adverts on the Greenhouse board on 12 November 2026 are located "US- Remote", and the careers page says "We are primarily remote, meaning we hire from anywhere in the United States." The same page lists "100% remote with frequent all team, in-person meetings to build relationships and problem solve" among its benefits. Five adverts say "Remote working environment with frequent in-person meetings to address complex problems and build relationships." and the Senior Scientist, Translational Science advert says "100% remote team with frequent in-person meetings to build relationships and problem solve." No advert or page says how often the in-person meetings take place, where they are held, how long they last or who pays for travel, and none uses the word hybrid or mentions office days, on-site work or relocation. The contact page gives a Waltham, Massachusetts address (221 Crescent Street, Suite 105) and no page describes it as an office. The site footer says "For U.S. residents only", and the board lists no roles outside the United States.
What is the Spyre Therapeutics team like?
The six open roles are corporate and clinical-development positions, and no advert describes bench, wet-lab or shift work. Four sit in Clinical Development (a Clinical Scientist; a Director, Drug Safety Physician; a Senior Director, Drug Safety and Pharmacovigilance Operations; and a Senior Scientist, Translational Science), one in Regulatory (Director, Regulatory Affairs) and one in Legal (Senior Director, Intellectual Property Counsel). Four of the six are director or senior director roles, and the advertised salary ranges run from $144,000 to $336,000. Several roles work through outside partners: the Clinical Scientist advert says the role will "act as a bridge between internal teams, external investigators and CRO partners", the Senior Scientist advert says the job is to manage "outsourced bioanalytical activities for pharmacokinetic, immunogenicity, and/or biomarker assays conducted at CROs", and the Senior Director, Drug Safety and Pharmacovigilance Operations advert describes the role as the "subject matter expert for outsourced safety operations". The adverts call Spyre "our young company", and five say "fast-paced, dynamic environment" while the sixth says "fast-paced, highly dynamic environment"; two adverts and the careers page add "wear multiple hats". The careers page lists three values, Breakthrough Discoveries, Courageous Dissent and Ownership Mindset, and describes the last as "We act like owners - driving rigorous, high-quality work with urgency and accountability for outcomes."
Work-Life Balance
All six adverts list "Unlimited PTO" under What We Offer, across Clinical Development, Regulatory and Legal. Each follows it with a second time-off perk: five say "Two, one-week company-wide shutdowns each" (the sentence stops there in those five) and the Senior Scientist, Translational Science advert says "Two, one-week company-wide shutdowns each year." The careers page benefits list words the same two perks as "Flexible PTO and two, one-week company-wide shutdowns each year", so the company page says flexible rather than unlimited. No page or advert gives a number of days, weekly hours, core hours or flexible start and finish times, and none mentions shifts, on-call or weekend work. The pace is described as "fast-paced, dynamic environment" in five adverts, and all six adverts call the in-person meetings described above "frequent"; they do not say how often the meetings happen, so the travel involved is not specified.
Perks and Benefits
- Unlimited PTO in all 6 adverts (the careers page calls it "Flexible PTO")
- Two, one-week company-wide shutdowns each year (careers page and one advert; the other five adverts end the sentence at "each")
- Competitive compensation inclusive of base salary, performance bonus, equity grant opportunities, and retirement benefits (careers page)
- Coverage inclusive of medical, dental, vision, health and wellness reimbursements (careers page)
- Professional development: "We are committed to growing you professionally and providing access to resources to further your development." (careers page)
- A primarily remote team that hires from anywhere in the United States, with frequent in-person meetings
- A stated salary range in every advert